Ivars Kalvinsh Selected Research

3-(2,2,2-trimethylhydrazine)propionate

5/2013	Mildronate enhances learning/memory and changes hippocampal protein expression in trained rats.
1/2013	Mildronate and its neuroregulatory mechanisms: targeting the mitochondria, neuroinflammation, and protein expression.
6/2012	The cardioprotective effect of mildronate is diminished after co-treatment with L-carnitine.
1/2012	Search for stroke-protecting agents in endothelin-1-induced ischemic stroke model in rats.
1/2011	Mildronate as a regulator of protein expression in a rat model of Parkinson's disease.
1/2011	Administration of L-carnitine and mildronate improves endothelial function and decreases mortality in hypertensive Dahl rats.
1/2011	Correction of glycaemia and GLUT1 level by mildronate in rat streptozotocin diabetes mellitus model.
11/2010	Neuroprotective properties of mildronate, a small molecule, in a rat model of Parkinson's disease.
9/2010	Mildronate exerts acute anticonvulsant and antihypnotic effects.
8/2009	Protective effects of mildronate in an experimental model of type 2 diabetes in Goto-Kakizaki rats.

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Ivars Kalvinsh Research Topics

Disease

8	Ischemia 05/2013 - 06/2002
6	Infarction (Infarctions) 01/2014 - 06/2002
5	Inflammation (Inflammations) 01/2013 - 12/2005
3	Parkinson Disease (Parkinson's Disease) 05/2013 - 11/2010
3	Encephalitis (Encephalitis, Rasmussen) 12/2007 - 12/2005
2	Hyperglycemia 01/2017 - 01/2012
2	Body Weight (Weight, Body) 01/2017 - 12/2007
2	Seizures (Absence Seizure) 10/2015 - 09/2010
2	Hypertension (High Blood Pressure) 01/2014 - 01/2011
2	Neoplasms (Cancer) 11/2013 - 03/2009
2	Neurodegenerative Diseases (Neurodegenerative Disease) 05/2013 - 11/2010
2	Neuroinflammatory Diseases 01/2013 - 01/2004
2	Diabetes Mellitus 01/2012 - 07/2010
2	Experimental Diabetes Mellitus 01/2011 - 07/2010
2	Necrosis 08/2009 - 03/2006
2	Myocardial Infarction 08/2009 - 03/2006
2	Pain (Aches) 08/2009 - 03/2008
2	Coronary Occlusion 08/2009 - 06/2002
2	Cardiac Arrhythmias (Arrythmia) 08/2009 - 06/2002
2	Mitochondrial Diseases (Mitochondrial Disease) 09/2008 - 10/2006
1	Metabolic Syndrome (Dysmetabolic Syndrome X) 01/2017
1	Obesity 01/2017
1	Weight Gain 01/2017
1	Hyperalgesia 10/2015
1	Neuralgia (Stump Neuralgia) 10/2015
1	Dementia (Dementias) 05/2013
1	Ischemic Stroke 01/2012
1	Stroke (Strokes) 01/2012
1	Cardiomegaly (Heart Hypertrophy) 01/2011
1	Diabetic Nephropathies (Diabetic Nephropathy) 07/2010
1	Type 2 Diabetes Mellitus (MODY) 08/2009
1	Reperfusion Injury 08/2009
1	Diabetes Complications 08/2009
1	Atherosclerotic Plaque (Atheroma) 01/2009
1	Atherosclerosis 01/2009
1	Cardiotoxicity 09/2008

Drug/Important Bio-Agent (IBA)

18	3-(2,2,2-trimethylhydrazine)propionateIBA 05/2013 - 08/2002
5	Proteins (Proteins, Gene)FDA Link 01/2013 - 07/2010
5	Carnitine (L-Carnitine)FDA LinkGeneric 06/2012 - 12/2006
4	gamma-butyrobetaine (butyrobetaine)IBA 05/2013 - 01/2004
3	Blood Glucose (Blood Sugar)IBA 01/2017 - 08/2009
3	Zidovudine (Retrovir)FDA LinkGeneric 05/2013 - 10/2006
3	Fatty Acids (Saturated Fatty Acids)IBA 06/2012 - 03/2006
3	Pharmaceutical PreparationsIBA 01/2012 - 08/2002
3	Peptides (Polypeptides)IBA 11/2010 - 01/2004
3	MelanocortinsIBA 06/2006 - 01/2004
2	Glucose (Dextrose)FDA LinkGeneric 01/2017 - 08/2009
2	4-amino-3-phenylbutyric acid (phenibut)IBA 10/2015 - 03/2008
2	PropionatesIBA 05/2013 - 08/2002
2	Streptozocin (Streptozotocin)FDA Link 01/2012 - 07/2010
2	SaltsIBA 01/2011 - 08/2009
2	NF-kappa B (NF-kB)IBA 09/2008 - 12/2005
2	Melanocortin Receptors (Melanocortin Receptor)IBA 12/2007 - 12/2005
2	Nitric Oxide (Nitrogen Monoxide)FDA Link 12/2007 - 06/2006
2	1- (3,4- dimethoxy- 2- - chlorobenzylideneamino)guanidineIBA 08/2004 - 06/2002
2	Guanidine (Guanidine Nitrate)FDA Link 08/2004 - 06/2002
1	Appetite Depressants (Anorectics)IBA 01/2017
1	S-phenylpiracetamIBA 01/2017
1	LeptinIBA 01/2017
1	Pentylenetetrazole (Metrazol)IBA 10/2015
1	NitritesIBA 01/2014
1	MagnesiumIBA 01/2014
1	magnesium nitrateIBA 01/2014
1	NitratesIBA 01/2014
1	Nicotinamide PhosphoribosyltransferaseIBA 11/2013
1	Neuroprotective AgentsIBA 05/2013
1	Nootropic Agents (Nootropics)IBA 05/2013
1	2- cyclohexylidenhydrazo- 4- phenyl- thiazoleIBA 06/2012
1	Cytochromes c (Cytochrome c)IBA 06/2012
1	2,6- dimethyl- 3,5- bis(2'- propoxyethoxycarbonyl)- 4- (2''- difluoromethoxyphenyl)- 1,4- dihydropyridineIBA 01/2012
1	Glyburide (Glibenclamide)FDA LinkGeneric 01/2012
1	1,4-dihydropyridine (dihydropyridine)IBA 01/2012
1	Insulin (Novolin)FDA Link 01/2012
1	Endothelin-1 (Endothelin 1)IBA 01/2012
1	Therapeutic UsesIBA 01/2011
1	Proteasome Endopeptidase Complex (Proteasome)IBA 11/2010
1	Oxidopamine (6 Hydroxydopamine)IBA 11/2010
1	Glial Fibrillary Acidic ProteinIBA 11/2010
1	Nitric Oxide Synthase Type II (Inducible Nitric Oxide Synthase)IBA 11/2010
1	Tyrosine 3-Monooxygenase (Tyrosine Hydroxylase)IBA 11/2010
1	Biomarkers (Surrogate Marker)IBA 11/2010
1	UbiquitinIBA 11/2010
1	NeurotoxinsIBA 11/2010
1	Facilitative Glucose Transport Proteins (Glucose Transporter)IBA 07/2010
1	Metformin (Glucophage)FDA LinkGeneric 07/2010
1	Anti-Arrhythmia AgentsIBA 08/2009
1	CarbohydratesIBA 08/2009
1	Isoproterenol (Isoprenaline)FDA LinkGeneric 08/2009
1	Orotic AcidIBA 08/2009
1	Phenylephrine (Neo-Synephrine)FDA LinkGeneric 08/2009
1	FructosamineIBA 08/2009
1	Histone Deacetylases (Histone Deacetylase)IBA 03/2009
1	Apolipoproteins E (ApoE)IBA 01/2009
1	CholesterolIBA 01/2009
1	EnzymesIBA 09/2008
1	Antidepressive Agents (Antidepressants)IBA 03/2008
1	Type 4 Melanocortin Receptor (Melanocortin-4 Receptor)IBA 12/2007
1	melanotan-IIIBA 12/2007
1	LipopolysaccharidesIBA 12/2007

Therapy/Procedure

2	Therapeutics 11/2013 - 10/2006